Publications 2008
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
Schilling St, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner Ch, Rudolph T, Reuter G, Cynis H, Montag D, Demuth H-U & Rossner St
Nature Medicine, 2008, 14, 1106-1111 (doi:10.1038/nm.1872)
pGlu-Amyloid Peptide Formation is Mediated by Glutaminyl Cyclase in Mammalian Cells: Implications For a New Treatment Strategy for Alzheimer's Disease
Cynis H, Scheel E, Saido TC, Schilling St and Demuth H-U.
Biochemistry 2008, 47, 7405-7413
Efficacy of Dipeptidyl Peptidase IV inhibitor Isoleucine-thiazolidide (P32/98) in fatty (fa/fa) Zucker rats with incipient and manifest glucose intolerance.
Augstein P, Berg S, Heinke P, Altmann S, Salzsieder E, Demuth HU, Kühn-Wache K, Heins J, Freyse EJ
Diabetes, Obesity and Metabolism 2008, 10, 850 - 861
Isoaspartate containing amyloid precursor protein derived peptides alter efficacy and specifity of potential beta-secretases
Böhme L, Hoffmann T, Manhart S, Wolf R and Demuth H-U
Biological Chemistry 2008, 389, 1055-1066
Inhibition of CD26/Dipeptidyl Peptidase IV Enhances CCL11/Eotaxin-Mediated Recruitment of Eosinophils In Vivo
Forssmann U, Stoetzer C, Stephan M, Kruschinski C, Skripuletz T, Schade J, Schmiedl A, Pabst R, Wagner L, Hoffmann T, Kehlen A, Escher SE, Forssmann W-G, Elsner J, von Hoersten St.
J Immun (2008), 181; 1120-1127
Inhibition of Glutaminyl Cyclase prevents pGlu-Abeta formation after intracortical/hippocampal Microinjection in vivo/in situ
Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU
J. Neurochemistry 2008, 106, 12325-12336
Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-beta.
Holger Cynis, Eike Scheel, Takaomi C. Saido, Stephan Schilling, Hans-Ulrich Demuth
Biochemistry 2008, 47, 7405-7413
Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery
Holger Cynis; Jens-Ulrich Rahfeld; Anett Stephan; Birgit Koch; Michael Wermann; Hans-Ulrich Demuth; Stephan Schilling
J Mol Biol 2008, 379, 966-980
Isoaspartate residues dramatically influence substrate recognition and turnover by proteases.
Böhme L, Bär JW, Hoffmann T, Manhart S, Ludwig H-H, Rosche F and Demuth H-U
Biological Chemistry 2008, 389, 1043-1053
Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer's Disease
Vivian Hook; Isreal Schechter; Hans-Ulrich Demuth; Gregory Hook
Biological Chemistry 2008, 389, 993-1006
Glutaminyl Cyclases from Animals and Plants: A Case of Functionally Convergent Protein Evolution.
Stephan Schilling; Claus Wasternack; Hans-Ulrich Demuth
Biological Chemistry 2008, 389, 983-991
Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats
Jutta Schade; Michael Stephan; Andreas Schmiedl; Leona Wagner; André J. Niestroj; Hans-Ulrich Demuth; Nadine Frerker; Christian Klemann; Kerstin Raber; Reinhard Pabst; Stephan von Hörsten
Journal Histochem. Cytochem. 2008, 56, 147-155
Novel Inhibitor for Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis and Details of Substrate-Recognition Mechanism.
Yue Xu; Yoshitaka Nakajima; Kiyoshi Ito; Heng Zheng; Hiroshi Oyama, Ulrich Heiser; Torsten Hoffmann; Ulf-Torsten Gärtner; Hans-Ulrich Demuth; Tadashi Yoshimoto
Journal Mol. Biol. 2008, 375, 708-719