Publications 2003

Identification of Human Glutaminyl Cyclase as a Metalloenzyme
Schilling St, Niestroj AJ, Rahfeld JU, Hoffmann T, Wermann M, Zunkel K, Wasternack C, Demuth HU.
J Biol Chemistry, 2003, 278, 49773-49779

Substrate Specificity of Glutaminyl Cyclases from Plants and Animals
Schilling, S.; Manhart, S.; Hoffmann, T.; Ludwig, H.-H.; Wasternack, C.; Demuth, H.-U.
J. Biol. Chem., 2003, 384 (12) 1583-1592

Characterisation of Human Dipeptidyl Peptidase IV Expressed in Pichia Pastoris
A Structural and Mechanistic Comparison between the Recombinant Human and the Purified Porcine Enzyme
Bär, J.; Weber, A.; Hoffmann, T.; Stork, J.; Wermann, M.; Wagner, L.; Aust, S.; Gerhartz, B.; Demuth, H.-U.
J. Biol. Chem. 2003, 384 (12) 1553-1563

Potent and Specific Inhibition of Human Glutaminyl Cyclase by Imidazole Derivatives Reveals it as Metalloenzyme.
Schilling, S.; Niestroj, A.J.; Rahfeld, J.-U.; Hoffmann, T.; Wermann, M.; Zunkel, K.; Wasternack, C.; Demuth, H.-U.
J. Biol. Chem., 2003, 278, 49773-49779

Quantitative analysis of DP IV-Inhibitor P32/98 and its main metabolite in biological fluids using LC-MS/MS: application to pharmacokinetic evaluation
Meyer, A.; Gourinchas, E.; Girault, J.; Demuth, H.-U.
J. Chromatogr. B, 2003, 796, 401-411

Glucose-dependent insulinotropic polypeptide (GIP) regulates ß-(INS-1) cell survival via cAMP-mediated caspase-3/9 inhibition and MKK3/6, p38 MAPK, ATF-2 regulation
Ehses, J.; Casilla, V.R.; Doty, T.; Posoisilik, J.A.; Demuth, H.-U.; Pederson, R.A.; McIntosh, C.H.S.
Endocrinology 2003, 144(10) 4433-4445

Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats.
Karl T.; Chwalisz W.T.; Wedekind D.; Hedrich H.J.; Hoffmann T.; Jacobs R.; Pabst R.; von Hörsten S.
Regul Pept. 2003, 115(2) 81-90.

Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity.
Karl T.; Hoffmann T.; Pabst R.; von Hörsten S.
Pharmacol Biochem Behav. 2003, 75(4) 869-879

Inhibition of Dipeptidyl Peptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLa-4 (CD152) in Stress-Induced Abortions.
Rüter, J.; Hoffmann, T.; Heiser, U.; Demuth, H.-U.; Reutter, W.; Klapp, B.F.; Hildebrandt, M.
Clin. Immunology 2003, 220, 150-156

Dipeptidyl Aminopeptidases in Health and Disease
Hildebrandt, M.; Klapp, B.; Hoffmann, T.; Demuth, H.-U.
Advances in experimental medicine and Biology 524, March 2003, 392 pp.

The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism.
Engel, M.; Hoffmann, T.; Wagner, L.; Wermann, M.; Heiser, U.; Kiefersauer, R.; Huber, R.; Bode, W.; Demuth, H.-U.; Brandstetter, H.
Proc. Nat. Acad. Sci. USA, 2003, 100(9), 5063-5068

Sructure-function analysis of a series of novel GIP-analogs containing different helical length linkers.
Manhart, S.; Hinke, S.A.; McIntosh, C.H.S.; Pederson, R.A.; Demuth, H.-U.
Biochemistry 2003, 42 (10), 3081-3088

DP IV-Inhibitor Treatment Stimulates ß-cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats.
Pospisilik, J.A.; Martin, J.; Doty, T.; Ehses, J.A.; Pamir, N.; Lynn F.C.; Piteau, S.; Demuth, H.-U.; McIntosh, C.H.S.; Pederson, R.A.
Diabetes 2003, 52, 741-750