2011
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
Hillmann A, Hahn St, Schilling St, Hoffmann T, Demuth H-U, Bulic B, Schneider-Axmann T, Bayer TA, Weggen S, Wirths O.
Neurobiology of Aging, 2011, online 22 Sept.
Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus.
Carrillo DR, Parthier C, Jänckel N, Grandke J, Stelter M, Schilling St, Boehme M, Neumann P, Wolf R, Demuth HU, Stubbs MT, Rahfeld JU.
Biol Chem 2010, 391, 1419–1428
Highlight: dipeptidyl peptidase 4 and related proteins.
Hoffmann T and Demuth HU.
Biological Chemistry 2011, 392, 151-152
Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate specific secondary binding site.
Kühn-Wache K, Bär J W, Hoffmann T, Wolf R, Rahfeld JU, Demuth HU.
Biol Chem 2011, 392, 223–231
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate Abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer T A.
J. Biol. Chem. 2011, 286, 4454–4460
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.
J Biol Chem 2011, 286, 14199-14208
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.
Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S.
Acta Neuropathol 2011, 121, 705-719
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld J-U, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PHA, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU.
EMBO Molecular Medicine 2011, 9 (3), 545-558
Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center.
Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Rahfeld, JU, Stubbs M, Schilling S, Demuth HU.
Biochemistry 2011, 50 (28), 6280-88
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.
Wagner L, Wermann M, Rosche F, Rahfeld JU, Hoffmann T, Demuth HU.
Biol Chem 2011, 392 (7), 665-677
Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ is Induced by pyro-Glu-Aβ Formation
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann St, Sedlmeier R, Raber K, Cynis H, Rönicke R, Reymann K, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling St, Osmand A, Demuth HU, von Hörsten S.
J Neurosci 2011, 31 (36), 12790-12801
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-kappaB signaling pathway
Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU.
J Neuroinflammation, 2011 Jul 29;8(1), 86